DEDAL input form on Essentia Proteomica server.
DEDAL is a protein structure alignment tool which is independent of rigid-body constraints.
This is carried out by systematically evaluating local structure context to identify similar regions of proteins.
By focusing on local structure and performing a spatial rather than sequence attached analysis of matching
substructures it is not constrained by any particular order of structural features along the protein sequence.
Because it identifies all local similarities between compared structures, it offers a rigorous and complete analysis.
It is also very conservative in not extending the structure-based sequence alignment, beyond regions of pronounced structure similarity.
Binary distribution of DEDAL is also available:
When publishing results using DEDAL, please cite the following work:
P. Daniluk, B. Lesyng, A novel method to compare protein structures using local descriptors, BMC Bioinformatics 2011, 12:344