You are here

Research

We have been developing and applying quantum and classical multiscale molecular modeling methods, as well as methods of bioinformatics and biomedical informatics. In particular, we have been dealing with:

Currently two infrastrastructure and research grants are being carried out in:

  • POIG.02.03.00-00-003/09, „Applications of digital technologies in medicine”, which is carried out based on a common project of the Polish Academy of Sciences research institutions – „Biocentrum Ochota – information infrastructure for the strategic areas of biology and medicine”(read more),
  • D/NZ2/05314, „Development of a method for the structure prediction of GPCRs complexes with agonists and antagonists, including the ligand-induced alternations of the receptor structure” (read more).

Regarding  POIG.02.03.00-00-003/09, the following four laboratories are being created:

  • Laboratory of Molecular Medicine and Bioinformatics,
  • Laboratory of Biomedical Signals,
  • Laboratory of Biomedical Imaging,
  • Laboratory of Telemedicine.

Three prototypes of the following services are being created:

Regarding D/NZ2/05314, the purpose is to develop an efficient method to predicting 3D structures of complexes consisted of GPCR receptors with their agonists or antagonists, including their mutual interactions. CABS-TP (CABS for Transmembrane Proteins) is a modified coarse-grained CABS model, being capable to efficiently sample the conformational protein space. It is planned to link CABS with a number of cellular membrane models, in particular with a macroscopic continuous one.